What do you need?
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Apache (mod_rewrite ON)
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PHP >= 5.5 (cURL + mcrypt + memcache + mbstring)
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MySQL (optional for blacklist).
Instructions:
Step 1: download tarball (or clone repo) and upload to your server.
Step 2: install composer dependencies -> $ php composer.phar install
Step 3: remove ALL /config .sample extension and edit miscellaneous.php and any other file you need.
Step 4: prepare virtual host and point document root to megacrypter public dir.
Step 5 (optional): ask developers of your favourite download manager to recognize your new megacrypter links.
You're alone from here. Good luck!